Drug stability expiration dating

The dates on drug labels are simply the point up to which the Food and Drug Administration and pharmaceutical companies guarantee their effectiveness, typically at two or three years. health care system is the most expensive in the world.

But the dates don’t necessarily mean they’re ineffective immediately after they “expire” — just that there’s no incentive for drugmakers to study whether they could still be usable. One answer, broadly, is waste — some of it buried in practices that the medical establishment and the rest of us take for granted.

Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis.

Alprostadil was the least stable of the drug components at room temperature and under refrigeration.

Drug manufacturers are required to stamp an expiration date on their products.

On over-the-counter (OTC) medicines, the expiration date is often printed on the label or carton under "EXP" or stamped without ink into the bottom of a bottle, carton, or the crimp of a tube. Is a medicine still safe to take after its expiration date?

However, if you are looking for an intelligent rebuttal of expiration dates, the best place to turn is to the very same alphabet soup government agency, the FDA.

But to Lee Cantrell, who helps run the California Poison Control System, the cache was an opportunity to answer an enduring question about the actual shelf life of drugs: Could these drugs from the bell-bottom era still be potent?

Cantrell called Roy Gerona, a University of California, San Francisco, researcher who specializes in analyzing chemicals.

Pharmacies across the country — in major medical centers and in neighborhood strip malls — routinely toss out tons of scarce and potentially valuable prescription drugs when they hit their expiration dates.

Gerona and Cantrell, a pharmacist and toxicologist, knew that the term “expiration date” was a misnomer.